The N348I Mutation at the Connection Subdomain of HIV-1 Reverse Transcriptase Decreases Binding to Nevirapine
Open Access
- 1 December 2010
- journal article
- research article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 285 (49) , 38700-38709
- https://doi.org/10.1074/jbc.m110.153783
Abstract
No abstract availableKeywords
This publication has 62 references indexed in Scilit:
- N348I in HIV-1 Reverse Transcriptase Can Counteract the Nevirapine-mediated Bias toward RNase H Cleavage during Plus-strand InitiationJournal of Biological Chemistry, 2010
- N348I in HIV-1 reverse transcriptase decreases susceptibility to tenofovir and etravirine in combination with other resistance mutationsAIDS, 2010
- Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir ResistanceJournal of Biological Chemistry, 2009
- Mechanism of Inhibition of HIV-1 Reverse Transcriptase by 4′-Ethynyl-2-fluoro-2′-deoxyadenosine Triphosphate, a Translocation-defective Reverse Transcriptase InhibitorJournal of Biological Chemistry, 2009
- Reverse transcriptase in motion: Conformational dynamics of enzyme–substrate interactionsBiochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2009
- Clinical relevance of substitutions in the connection subdomain and RNase H domain of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naïve patientsAntiviral Research, 2009
- Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and InhibitionJournal of Molecular Biology, 2008
- HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excisionProceedings of the National Academy of Sciences, 2008
- Connection Domain Mutations N348I and A360V in HIV-1 Reverse Transcriptase Enhance Resistance to 3′-Azido-3′-deoxythymidine through Both RNase H-dependent and -independent MechanismsJournal of Biological Chemistry, 2008
- Mutations in the connection domain of HIV-1 reverse transcriptase increase 3′-azido-3′-deoxythymidine resistanceProceedings of the National Academy of Sciences, 2007