Complications of Anticoagulant Therapy

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Abstract
During the past decade there have been many studies on thromboembolic disease. Most authors agree that anticoagulant drugs are an important addition to the armamentarium. It is unfortunate that with the use of most new drugs, undesirable features appear that cannot be overlooked. The anticoagulants are no exception. The only known complication is hemorrhage, but there are numerous contraindications: blood dyscrasias manifesting hemorrhagic tendencies; large open surfaces with poorly controlled hemostasis after operation (especially liver and prostatic surgery); brain and spinal-cord surgery; active or imminent gastrointestinal ulceration or bleeding; malignant hypertension,1 particularly when there has been a previous cerebral hemorrhage; . . .