In-vitro studies with four new antifungal agents: BAY n7133, bifonazole (BAY h 4502), ICI 153,066 and Ro 14-4767/002

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Abstract
Four new antifungal agents were compared in vitro with miconazole and ketoconazole. The agents were BAY n 7133 and ICI 153,066, two orally active triazoles, and bifonazole (BAY h 4502) and Ro 14-4767/002, both topical agents. While all four were found to be broad spectrum antifungal agents they also demonstrated certain gaps in their spectra. In general, Ro 14-4767/002 was the most active agent tested whereas bifonazole and BAY n 7133 were the least active. Noteworthy activities included that of Ro 14-4767/002 against Candida albicans , the dermatophytes and Sporothrix schenckii and that of ICI 153,066 against Torulopsis glabrata .