Alterations of a maternally inherited mitochondrial structural protein in respiratory-deficient strains of Neurospora.
- 1 April 1966
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 55 (4) , 872-880
- https://doi.org/10.1073/pnas.55.4.872
Abstract
The mitochondrial structure protein (MSP) from 2 maternally inherited, respiratory-deficient mutants of Neurospora (mi-1 and mi-3) differs from wide-type MSP. The MSP from mi-1 has one less tryptophan residue per mole of MSP and one more cysteine residue than does wild-type MSP. The MSP from mi-4 also has one less tryptophan residue, but no other differences have yet been detected in amino-aoid composition. The mutations in mi-2 and mi-3 appear to result from alterations in mitochondrial DNA which in turn result in single amino-acid replacements. Based on the nucleocytoplasmic interactions that are described, which involve protein-protein interactions between malate dehydrogenase and mitochondrial structural protein, an explanation for the pleiotropic phenotype of mi-w and mi-4 is offered.This publication has 20 references indexed in Scilit:
- Purification and Properties of Neurospora AdenylosuccinaseJournal of Biological Chemistry, 1966
- The mitochondrial structural proteins from wild-type and respiratory-deficient yeastsBiochemical and Biophysical Research Communications, 1965
- Studies on polynucleotides, XLIX. Stimulation of the binding of aminoacyl-sRNA's to ribosomes by ribotrinucleotides and a survey of codon assignments for 20 amino acids.Proceedings of the National Academy of Sciences, 1965
- A procedure for molecular weight measurements: application to Chymotrypsinogen A.Proceedings of the National Academy of Sciences, 1965
- DNA IN MITOCHONDRIA OF NEUROSPORA CRASSAProceedings of the National Academy of Sciences, 1964
- The binding of phosphate, pyrophosphate, and nucleotides to the structural protein of beef heart mitochondriaArchives of Biochemistry and Biophysics, 1964
- SERINE DEAMINATION BY THE B PROTEIN OF ESCHERICHIA COLI TRYPTOPHAN SYNTHETASEProceedings of the National Academy of Sciences, 1964
- GENESIS OF MITOCHONDRIA IN NEUROSPORA CRASSAProceedings of the National Academy of Sciences, 1963
- Peptide pattern studies on the wild-type a protein of the tryptophan synthetase of Escherichia coliBiochimica et Biophysica Acta, 1962
- Physical Characteristics of Proteins of the Electron Transfer System and Interpretation of the Structure of the Mitochondrion*Biochemistry, 1962