STUDIES IN RODENT POLIOMYELITIS

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Abstract
A description has been given of the lesions produced in mice and guinea pigs by inoculation of the Jungeblut-Sanders virus. The histopathological findings, although in themselves not conclusive, would tend to support the opinion that Jungeblut and Sanders have transmitted the SK poliomyelitis virus to mouse and guinea pig. In mice the virus apparently retains its affinity for the anterior horns of the spinal cord, but in a moderate degree. Associated with a marked increase in virulence of the virus, a strong affinity for the cerebral tissues, more particularly the olfactory centers, develops. On transmitting this murine variant of the virus to guinea pigs, however, the original character of the virus is again revealed. There is a reversion to a predominant affinity for the nerve cells of the anterior horns of the spinal cord.