Lajollamycin, a Nitro-tetraene Spiro-β-lactone-γ-lactam Antibiotic from the Marine Actinomycete Streptomyces nodosus
- 21 January 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 68 (2) , 240-243
- https://doi.org/10.1021/np049725x
Abstract
A strain of Streptomyces nodosus (NPS007994) isolated from a marine sediment collected in Scripps Canyon, La Jolla, California, was found to produce lajollamycin (1), a nitro-tetraene spiro-β-lactone-γ-lactam antibiotic. The structure was established by complete analysis of spectroscopic data and comparison with known antibiotics oxazolomycin (2), 16-methyloxazolomycin (3), and triedimycin B (4). Lajollamycin (1) showed antimicrobial activity against both drug-sensitive and -resistant Gram-positive bacteria and inhibited the growth of B16-F10 tumor cells in vitro.Keywords
This publication has 7 references indexed in Scilit:
- New triene-.BETA.-lactone antibiotics, triedimycins A and B.The Journal of Antibiotics, 1991
- The biosynthesis of the antibiotic pyrrolnitrin by Pseudomonas aureofaciens.The Journal of Antibiotics, 1981
- Structure and synthesis of pyrrolomycin A. a chlorinated nitro-pyrrole antibiotic.The Journal of Antibiotics, 1981
- Structure of Pyrrolomycin B, A chlorinated nitro-pyrrole antibiotic.The Journal of Antibiotics, 1981
- Structure of everninomicin DJournal of the American Chemical Society, 1975
- BIOSYNTHESIS OF CHLORAMPHENICOL: II.p-AMINOPHENYLALANINE AS A PRECURSOR OF THEp-NITROPHENYLSERINOL MOIETYCanadian Journal of Biochemistry, 1967
- Chloramphenicol (Chloromycetin).1 IV.1a Chemical StudiesJournal of the American Chemical Society, 1949