Studies on Penicillinase

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Abstract
Antipenicillin-ase-immune serum was obtained by the injn. of rabbits with penicillinase. The combination of penicillinase and antipenicillinase and the consequent loss of activity of the former was demonstrated by inhibition tests and by a highly specific manometric method of assaying penicillinase. The sensitivity of a number of organisms to penicillin was detd. in the presence of normal serum and antipenicillinase-immune rabbit serum. Sensitivity to penicillin was increased only in those organisms which produced extracellular penicillinase. It appears that antipenicillinase-immune serum would be of limited value as a chemotherapeutic adjunct, except possibly in the case of certain mixed infections.