Synergy between Efflux Pump CmeABC and Modifications in Ribosomal Proteins L4 and L22 in Conferring Macrolide Resistance in Campylobacter jejuni and Campylobacter coli
- 1 November 2006
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (11) , 3893-3896
- https://doi.org/10.1128/aac.00616-06
Abstract
Macrolide-resistant mutants of Campylobacter jejuni and Campylobacter coli were selected in vitro using erythromycin and tylosin. These mutants exhibited modifications in the ribosomal proteins L4 (G74D) and L22 (insertions at position 86 or 98). A synergy between the CmeABC efflux pump and these modifications in conferring macrolide resistance was observed.Keywords
This publication has 18 references indexed in Scilit:
- Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.Microbes and Infection, 2006
- Antibiotics and the ribosomeMolecular Microbiology, 2006
- Major Structural Differences and Novel Potential Virulence Mechanisms from the Genomes of Multiple Campylobacter SpeciesPLoS Biology, 2005
- Inability of L22 ribosomal protein alteration to increase macrolide MICs in the absence of efflux mechanism in Haemophilus influenzae HMC-SJournal of Antimicrobial Chemotherapy, 2004
- Campylobacter infection in 682 bulgarian patients with acute enterocolitis, inflammatory bowel disease, and other chronic intestinal diseasesDiagnostic Microbiology and Infectious Disease, 2004
- Resistance to Macrolide, Lincosamide, Streptogramin, Ketolide, and Oxazolidinone AntibioticsMolecular Biotechnology, 2004
- Selection and Characterization of Fluoroquinolone-Resistant Mutants ofCampylobacter jejuniUsing EnrofloxacinMicrobial Drug Resistance, 2002
- L22 Ribosomal Protein and Effect of Its Mutation on Ribosome Resistance to ErythromycinJournal of Molecular Biology, 2002
- Resistance to Quinupristin-Dalfopristin Due to Mutation of L22 Ribosomal Protein inStaphylococcus aureusAntimicrobial Agents and Chemotherapy, 2002
- High Resolution Structure of the Large Ribosomal Subunit from a Mesophilic EubacteriumPublished by Elsevier ,2001