Sensitive assays for hepatitis a antibodies

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Abstract
Two commercial assay kits for detecting antibody to hepatitis A virus (anti‐HAV) have been modified in order to increase their sensitivity. These modifications are made by less dilution of the test serum, in the case of Abbott HAVAB‐M assay, or by an increase in the volumetric ratio of the test serum to the labeled anti‐HAV in the case of the Abbott HAVAB assay. These modifications result in 5‐ to 20‐fold increases in test sensitivity and enable the detection of anti‐HAV at 2–3 weeks following vaccination. The earlier detection of anti‐HAV is important to vaccine development in assuring the presence of antibody levels in travelers sooner after vaccination.