The Anti-Rh0(D) Responses of Immunized Volunteers following Repeated Antigenic Stimuli

Publisher Website
Google Scholar
Abstract
Rh0(D) negative [human] male volunteers (29) previously immunized with D-positive red cells received a series of antigenic stimuli repeated every 2 or 4 wk. Although there is an individual variation in the magnitude of the anti-D responses, the levels of anti-D achieved are, in general, higher than those obtained after stimuli spaced at intervals of several months. Certain volunteers whose plasma was not suitable for inclusion into pools for the preparation of anti-D immunoglobulin could, after spaced stimuli, donate regularly following the repeated stimuli. Although negative clinical reactions did not occur as a result of the repeated stimuli, 5 volunteers developed unwanted antibodies outside the Rh system; this may be related to the total dose of red cells injected.