Effects of heterologous anti-lymphocyte serum on the distribution of 51-Cr-labelled lymph node cells in mice.
- 1 November 1968
- journal article
- Vol. 15 (5) , 633-42
Abstract
The effects of heterologous anti-lymphocyte serum (ALS) were studied in a syngeneic cell transfer system, in which lymph node cells from donor CBA mice were labelled in vitro with 51Cr and transferred intravenously into syngeneic recipients. Labelled cells treated in vitro with ALS were unable to migrate to lymph nodes or spleens of recipients, as did normal cells, but instead distributed themselves very similarly to cells which had been killed by exposure to heat. It is thus likely that cells treated in vitro with ALS are killed after transfer by the cytotoxic action of ALS mediated by the complement of the recipient.This publication has 15 references indexed in Scilit:
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