MODE OF ACTION OF ANTI-LYMPHOCYTE GLOBULIN .I. DISTRIBUTION OF RABBIT ANTI-LYMPHOCYTE GLOBULIN INJECTED INTO RATS AND MICE

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  • 1 January 1968
    • journal article
    • research article
    • Vol. 14  (1) , 107-+
Abstract
The distribution of rabbit anti-lymphocyte globulin (IgG) following injection into rats and mice was studied by immunofluores-cence and 131I labelling and the tissues from treated animals examined by electron-microscopy. The anti-lymphocyte globulin reacts primarily with circulating lymphocytes, and penetrates the thymus, spleen and lymph nodes to a limited extent. These findings may explain the selective immunosuppressive action of anti-lymphocyte globulin.