Setting the Record Straight in the Breast-Cancer Trials
- 19 May 1994
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 330 (20) , 1448-1450
- https://doi.org/10.1056/nejm199405193302010
Abstract
In 1985 the Journal published a paper from the multicenter National Surgical Adjuvant Breast and Bowel Project (NSABP) showing that lumpectomy was as effective as mastectomy in the treatment of early breast cancer1. A follow-up paper in 1989 confirmed the finding2. It was published in the Journal along with two other papers from the NSABP: one showing that adjuvant chemotherapy was effective for node-negative, estrogen-receptor-negative breast cancer,3 and the other showing that tamoxifen was effective for node-negative, estrogen-receptor-positive breast cancer4. The trials (known as Protocols B-06, B-13, and B-14) were coordinated by Dr. Bernard Fisher of the . . .Keywords
This publication has 14 references indexed in Scilit:
- Fraud in Breast-Cancer TrialsNew England Journal of Medicine, 1994
- Treatment differences and other prognostic factors related to breast cancer survival. Delivery systems and medical outcomesPublished by American Medical Association (AMA) ,1994
- NCI Issues Information on Falsified Data in NSABP TrialsJNCI Journal of the National Cancer Institute, 1994
- Lumpectomy Compared with Lumpectomy and Radiation Therapy for the Treatment of Intraductal Breast CancerNew England Journal of Medicine, 1993
- Breast conservation is the treatment of choice in small breast cancer: Long-term results of a randomized trialEuropean Journal of Cancer and Clinical Oncology, 1990
- Eight-Year Results of a Randomized Clinical Trial Comparing Total Mastectomy and Lumpectomy with or without Irradiation in the Treatment of Breast CancerNew England Journal of Medicine, 1989
- Ten-year results of a randomized trial comparing a conservative treatment to mastectomy in early breast cancerRadiotherapy and Oncology, 1989
- A Randomized Clinical Trial Evaluating Tamoxifen in the Treatment of Patients with Node-Negative Breast Cancer Who Have Estrogen-Receptor–Positive TumorsNew England Journal of Medicine, 1989
- A Randomized Clinical Trial Evaluating Sequential Methotrexate and Fluorouracil in the Treatment of Patients with Node-Negative Breast Cancer Who Have Estrogen-Receptor-Negative TumorsNew England Journal of Medicine, 1989
- Five-Year Results of a Randomized Clinical Trial Comparing Total Mastectomy and Segmental Mastectomy with or without Radiation in the Treatment of Breast CancerNew England Journal of Medicine, 1985