THE STAGES IN CALCIFICATION OF THE RAT KIDNEY AFTER THE ADMINISTRATION OF URANIUM NITRATE
Open Access
- 1 May 1953
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 97 (5) , 681-694
- https://doi.org/10.1084/jem.97.5.681
Abstract
The anatomical and histochemical alterations in rat kidneys after the parenteral administration of uranium nitrate [UO2(NO3)2·6H2O] have been studied. The histological effects produced by this agent over a wide range of dose levels were nearly identical in character and differed principally in their speed of evolution. The deposition of calcium always began at foci in the cytoplasm of the cells of the proximal convoluted tubules of the inner cortex. It remained intracellular until the cell boundaries were destroyed.Keywords
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