Antitumor activity of 2-acylamino-1,3,4-thiadiazoles and related compounds.
- 1 January 1982
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 30 (12) , 4402-4406
- https://doi.org/10.1248/cpb.30.4402
Abstract
2-Nitrosoureido-1,3,4-thiadiazoles were effective against both mouse lymphoid leukemia L1210 and rat ascites hepatoma AH13. Some 2-acylamino-1,3,4-thiadiazoles were also effective against L1210. The anti-L1210 action of these 2-acylamino-1,3,4-thiadiazoles was blocked by administration of nicotinamide. Among these compounds, 2-propanoylamino-1,3,4-thiadiazole was the most effective against L1210, with a maximum T/C % of 166.This publication has 2 references indexed in Scilit:
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- Syntheses of the Amides Derived from Heterocyclic Acids and Heterocyclic Amines and Their Antitumor ActivitiesYAKUGAKU ZASSHI, 1976