A 32‐kDa protein associated with phospholipase A2‐inhibitory activity from human placenta
- 2 November 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 223 (2) , 267-272
- https://doi.org/10.1016/0014-5793(87)80302-2
Abstract
Two monomeric 32‐kDa proteins, termed 32K‐I (pI 5.8) and 32K‐II (pI 5.1), were isolated from human placenta, which was solubilized by a Ca2+‐chelator. Only 32K‐I was associated with PLA2‐inhibitory activity. CNBr peptide mapping indicated that 32K‐I was distinct from 32K‐II and two 36‐kDa proteins, called calpactin I and II or lipocortin II and I, which have been shown to possess PLA2‐inhibitory activity. 32K‐I bound to PS in a Ca2+‐dependent manner. 32K‐I was detected in many tissues except brain, cardiac and skeletal muscle.Keywords
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