The expression of creatine kinase isozymes in human cultured cells
- 28 September 2007
- journal article
- Published by Wiley in Annals of Human Genetics
- Vol. 43 (1) , 15-26
- https://doi.org/10.1111/j.1469-1809.1979.tb01545.x
Abstract
The BB isozyme of creatine kinase is consistently present in cultured human fibroblasts and shows great variation in activity in long-term lymphoid lines. One mouse line tested, PG 19, had strong activity, but all other rodent lines tested did not express CK BB. Human and mouse CK BB can be expressed independently of each other in human--rodent somatic cell hybrids. There is some evidence that the structural locus for CK BB may be on chromosome 14, but the involvement of other chromosomes, expecially no.17, cannot be excluded. The MM and MB isozymes of creatine kinase were not seen in any human cultured cells.Keywords
This publication has 14 references indexed in Scilit:
- Assignment of the human acid α‐glucosidase gene (αGLU) to chromosome 17 using somatic cell hybridsAnnals of Human Genetics, 1979
- Assignment of the DIA1 locus to chromosome 22Annals of Human Genetics, 1977
- Chromosome assignment of a human gene for argininosuccinate synthetase expression in Chinese hamster X human somatic cell hybridsExperimental Cell Research, 1977
- Evidence for the assignment of the loci AK1, AK3 and ACONs to chromosome 9 in manAnnals of Human Genetics, 1976
- Chromosome assignment of some human enzyme loci: mitochondrial malate dehydrogenase to 7, mannosephosphate isomerase and pyruvate kinase to 15 and probably, esterase D to 13Annals of Human Genetics, 1975
- A hemagglutination inhibition technique for detection of immunoglobulins in supernatants of human lymphoblastoid cell linesCell, 1974
- Differential staining of human and mouse chromosomes in interspecific cell hybridsNature, 1974
- Studies of human alloantigens on man‐mouse hybrids: possible syntheny between hl‐a and p systemsEuropean Journal of Immunology, 1973
- Genetic Analysis with Man–Mouse Somatic Cell Hybrids: Linkage between Human Lactate Dehydrogenase B and Peptidase B GenesNature, 1970
- Creatine kinase: Evidence for a dimeric structureBiochemical and Biophysical Research Communications, 1965