Immunologic Aspects of Renal Disease

Publisher Website
Google Scholar
Abstract
DiscussionFrom the studies of different investigators it now seems clear that glomerulonephritis may be induced immunologically in the laboratory animal by three different mechanisms: by the introduction of an antiwhole-kidney, antiglomerulus or antiglomerular-basement-membrane serum; by the intravenous injection of foreign protein; and by the injection of bacteria or their products.Ortega and Mellors122 have confirmed that nephrotoxic globulin is deposited on the glomerular basement membrane after intravenous injection and that during the next six to nine days there is deposition of the recipient animals' own globulin in the areas corresponding to those where nephrotoxic globulin had previously been concentrated. . . .