A rapid‐kinetic study of the class C β‐lactamase of Enterobacter cloacae 908R
- 20 July 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 306 (2-3) , 108-112
- https://doi.org/10.1016/0014-5793(92)80979-q
Abstract
The individual rate constants for acylation and deacylation (k 2 and k 3, respectively) of the class C β-lactamase of Enterobacter cloacae 908R by ampicillin and carbenicillin have been determined. For several other β-lactams, the value of k 2 was too high to be determined and the k 2/k 3 ratio could be larger than 10,000. Branched pathways were also shown to occur with several penicillins and cephalosporins.Keywords
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