Asymmetric Inheritance of Oxidatively Damaged Proteins During Cytokinesis
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- 14 March 2003
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 299 (5613) , 1751-1753
- https://doi.org/10.1126/science.1080418
Abstract
Carbonylated proteins were visualized in single cells of the budding yeast Saccharomyces cerevisiae , revealing that they accumulate with replicative age. Furthermore, carbonylated proteins were not inherited by daughter cells during cytokinesis. Mother cells of a yeast strain lacking the sir2 gene, a life-span determinant, failed to retain oxidatively damaged proteins during cytokinesis. These findings suggest that a genetically determined, Sir2p-dependent asymmetric inheritance of oxidatively damaged proteins may contribute to free-radical defense and the fitness of newborn cells.Keywords
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