The genetic basis of non-disjunction: Increased incidence of hyperploidy in oocytes from F1 hybrid mice
- 1 November 1983
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 65 (1) , 56-60
- https://doi.org/10.1007/bf00285029
Abstract
Oocytes from parental mice strains NMRI/Han, C57/bl and Balb/c and from F1 hybrid lines were analysed for aneuploidy due to non-disjunction after gonadotropin-stimulated ovulation. No hyperploid oocytes were present in five of the strains studied. F1 hybrids from crosses of NMRI/HanxC57/bl did ovulate, however, a significantly increased number of hyperploid oocytes, although females from their parental strains show a rather low incidence of non-disjunction. The evidence for a genetic basis for non-disjunction is assessed and possible causative factors are discussed.This publication has 14 references indexed in Scilit:
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