Influence of Body Composition on Adrenal Function in Obesity

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Abstract
A study of urinary steroid excretion and body composition was undertaken in 40 obese patients. Eleven patients were found to be hyperexcretors on the basis of urinary 17-OHCS levels greater than 10 mg/24 hr. Total body weight, lean body mass and body surface area were significantly different in the 2 groups of obese patients, but no difference of statistical significance between the groups in height, excess fat or creatinine excretion was demonstrated. Resting urinary 17-OHCS levels correlated best with the lean body mass, whereas following ACTH stimulation the best correlation of 17-OHCS excretion was with excess fat and total body weight. No correlation of 17-KS excretion with body composition measurements was found.