THE INHIBITION OF FATAL GRAFT-VERSUS-HOST DISEASE BY IMMUNIZATION OF DONOR OR HOST WITH BACILLUS CALMETTE-GUERIN CELL WALLS

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Abstract
F1 mice receiving sublethal whole-body x-irradiation (300 rads) or treatment with cyclophosphamide prior to the i.p. inoculation of parental spleen cells developed fatal graft-vs.-host disease (GVHD). A greater survival rate was obtained when the inoculated parenteral spleen cells were obtained from BCGcw[BCG cell walls]-preimmunized donors. The immunization of the F1 host with BCGcw also increased host survival. The combined treatment of preimmunizing the host with BCGcw and of using spleen cells from BCGcw-immunized parental donors to initate the GVHD resulted in producing the least severe GVHD and the greatest overall survival. The systemic transfer of x-irradiated spleen cells from BCGcw-immunized parental mice inhibited the fatal GVHD induced by the inoculation of normal parental spleen cells. BCGcw immunization of the host or obtaining parental spleen cells from BCGcw-immunized animals resulted in improving the overall survival rate in GVHD. BCGcw immunization induces suppressor cells and the decrease in GVHD that was observed was most likely due ot the induction of suppressor cells.