DEVELOPMENT OF 2 INBRED STRAINS OF RATS AND CHARACTERISTICS OF THEIR SKIN REACTIONS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 19  (4) , 151-158
Abstract
Two inbred strains of rats (Donryu and Sprague-Dawley strains) were developed. The skin reactions of these strains, immunized with Mycobacterium tuberculosis, hen egg albumin (OVA) or hen egg lysozyme and challenged with purified protein derivative (PPD) or each antigen, were even and uniform. The Donryu strain showed a typical Arthus reaction with petechiae and edema and a negligible delayed skin reaction, whereas the Sprague-Dawley strain showed a poor Arthus reaction and a typical delayed skin reaction with central necrosis and induration. The Arthus reaction or delayed skin reaction could be passively transferred to recipient rats of each strain by immune sera or sensitized peritoneal exudate cells (PEC), respectively.

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