A trial of therapy by nucleosides and nucleotides in muscular dystrophy
Open Access
- 1 April 1963
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 26 (2) , 111-122
- https://doi.org/10.1136/jnnp.26.2.111
Abstract
Six patients with Duchenne-type muscular dystrophy and 1 patient with the limb-girdle form were treated by intravenous infusions in Ringer''s solution of a nucleotide-nucleoside preparation (Laevadosin). Progress was evaluated by muscle strength measurements and assays of the serum enzymes aldolase, GOT and GPT. Results suggest some amelioration of the dystrophic process related to the therapy. Significant data pertaining to the Duchenne-type dystrophy can be obtained from SGOT and SGPT assays but serum aldolase assays seem to be necessary in the limb-girdle type dystrophy.Keywords
This publication has 41 references indexed in Scilit:
- Sources of error in the biochemical diagnosis of muscular dystrophyJournal of Neurology, Neurosurgery & Psychiatry, 1962
- An investigation of the carrier state in the Duchenne type muscular dystrophy*Annals of Human Genetics, 1961
- Maintenance of ambulation in childhood muscular dystrophyJournal of Chronic Diseases, 1960
- Mental Retardation in Association with Progressive Muscular DystrophyArchives of Pediatrics & Adolescent Medicine, 1960
- SIGNIFICANCE OF SERUM ALDOLASE LEVELSAnnals of the New York Academy of Sciences, 1958
- Nucleotide levels in human cardiac muscleAmerican Heart Journal, 1957
- Über die Behandlung der Dystrophia musculorum progressiva (Erb) mit AdenosintriphosphorsäureDeutsche Medizinische Wochenschrift (1946), 1957
- Serum Glutamic Pyruvic Transaminase in Cardiac and Hepatic Disease.Experimental Biology and Medicine, 1956
- Treatment of Muscular Dystrophy with Amino Acids and VitaminsNeurology, 1955
- ON THE CLASSIFICATION, NATURAL HISTORY AND TREATMENT OF THE MYOPATHIESBrain, 1954