STUDIES ON THE ROLE OF THE LIVER IN THE METABOLISM OF PROGESTERONE11

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Abstract
PROGESTERONE is inactivated in the body in the course of its metabolism (Zondek, 1939, 1941; Hamblen, Cuyler and Hirst, 1940). Pregnanediol-3(±),20(±) has been established as an end-product of progesterone metabolism in man (Venning and Browne, 1937; West-phal and Buxton, 1939) and in the rabbit (Heard, Bauld and Hoffman 1941; Westphal, 1942; Hoffman and Browne, 1942). Although pre-gnanediol 3(±), 20(±) is the only compound which has been shown con-clusively to be a metabolite of progesterone, it accounts for less than 25% of the progesterone administered to these species. The fate of the remainder is not known. Furthermore, little in known regarding the site or sites of metabo-lism of progesterone. Neither the ovary nor the uterus is essential for the conversion of progesterone into pregnanediol in the human female (Buxton, 1940; Venning and Browne, 1940; Jones and TeLinde, 1941) or in the female rabbit (Heard, Bauld and Hoffman, 1941). In the male rabbit this interconversion occurs in the absence of the testis (Hoffman and Browne, 1942).

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