Circadian clockwork: two loops are better than one
- 1 November 2000
- journal article
- review article
- Published by Springer Nature in Nature Reviews Neuroscience
- Vol. 1 (2) , 143-146
- https://doi.org/10.1038/35039080
Abstract
The spectacularly successful race over the past three years to place our understanding of the circadian clockwork of mammals into a molecular framework is beginning to yield the cardinal example of the molecular-genetic control of behaviour. This perspective describes recent evidence for the conservation of a double-loop, autoregulatory feedback mechanism across the best understood eukaryotic circadian systems, and discusses how these findings may illuminate some long-standing puzzles concerning our subliminal sense of circadian time.Keywords
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