Failure of Corn Oil and Triparanol to Prevent Hypercholesterolemia and Atherosclerosis.

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Abstract
Summary and conclusions 1. A diet high in polyunsaturated fat derived from corn oil did not prevent the development of hypercholesterolemia and atherosclerosis in rabbits fed cholesterol at the 1% and 0.25% levels. Aortic and hepatic sterol content increased greatly. 2. When triparanol, a potent inhibitor of cholesterol biosynthesis, was added to the corn oil-cholesterol feeding, it had no effect on the resulting hypercholesterolemia and atherosclerosis at the 0.05% level. Triparanol did appear to reduce aortic atherosclerosis slightly at a dose of 0.10% and under conditions of a lessened intake of dietary cholesterol. 3. The evidence to date is poor that atherosclerosis can be controlled by the use of either polyunsaturated oils in the diet or pharmacologic agents to inhibit cholesterol synthesis as long as significant amounts of cholesterol are absorbed in the body.