Radiolocalization of human prostate tumor in a mouse subrenal capsule model by monoclonal antibody turp-27

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Abstract
The subrenal capsule assay was used to determine if 125I‐labeled anti‐prostate monoclonal antibody TURP‐27 could target human prostate tumor fragments implanted under the renal capsule of normal immunocompetent C57 BL/6 mice. Maximal binding and optimal tumor to non‐tumor tissue ratios occurred within 24–48 hours postadministration of 125I‐TURP‐27. No significant localization was observed in mice bearing TURP‐27 antigen‐negative human colon tumor tissue implants or with an isotype‐matched control monoclonal antibody. These preclinical data suggest that TURP‐27 may have clinical application for imaging metastatic prostate tumors and further application in immunoconjugate and/or radiotherapy of prostate cancer.