THE EFFECT OF BROMOCRIPTINE ON INSULIN SECRETION AND GLUCOSE TOLERANCE IN PATIENTS WITH ACROMEGALY
- 1 November 1981
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 15 (5) , 473-478
- https://doi.org/10.1111/j.1365-2265.1981.tb00690.x
Abstract
The oral administration of bromocriptine 5 mg every 6 h to 12 patients with acromegaly for a mean period of 12 (range 3-27) mo. significantly reduced whole blood glucose, plasma insulin and plasma growth hormone (GH) concentrations during a 50 g oral glucose tolerance test (OGTT). After this period of treatment, bromocriptine was withdrawn for 48 h resulting in a significant rise in whole blood glucose, plasma insulin and plasma GH concentrations during a repeat OGTT. Bromocriptine therapy apparently improves glucose tolerance in acromegaly by suppressing GH secretion and consequently GH-mediated antagonism of insulin.This publication has 12 references indexed in Scilit:
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