Effect of D-Aldosterone on Cation Content of Isolated Rabbit Atria

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Abstract
The effects of the potent mineralosteroid d-aldosterone on K and Na content of stimulated and unstimulated isolated rabbit left atrial preparations have been studied. Isolation plus stimulation for 260 minutes produced a significant loss of total tissue K and significant gain of Na compared to freshly dissected controls. Addition of d-aldosterone (10−6M) to the perfusing fluid for one hour prior to analysis of cations failed to prevent this K loss or Na gain. A high concentration (10−5M) did significantly prevent the gain of Na, however. The data have been interpreted to mean that d-aldosterone does not promote active K accumulation in isolated heart muscle.