THE EFFECT OF QUANTITATIVE REDUCTION OF RENAL BLOOD FLOW UPON THE PREGNANT RABBIT

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Abstract
Quantitative degrees of renal ischemia were produced by applying clamps of known diam. to the previously measured aortae in pregnant and non-pregnant rabbits. In the pregnant animals marked ischemia produced a fall in blood pressure, N retention in the blood, and albuminuria with hematuria, while slight reduction was associated with hypertension and albuminuria without N retention. Only hypertension was noted in non-pregnant animals and in those in which delivery or resorption occurred. Uric acid elevation and hemoconc. were not noted. The similarity to "toxemia of pregnancy" in the human is discussed.

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