BINDING OF AGGREGATED IgG IN THE PRESENCE OF FRESH SERUM BY GROUP A STREPTOCOCCI PRODUCING PHARYNGEAL INFECTION: POSSIBLE CONNECTION WITH TYPES FREQUENTLY INVOLVED IN ACUTE NEPHRITIS

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Abstract
Streptococcal strains [109], belonging to diverse serological groups and types, were investigated for their capacity to bind Ig[immunoglobulin]G aggregates in the presence of fresh serum. Strains capable of such binding were not in groups B, C, D, E, G, L, M or N. Such binding was restricted to a few types of group A streptococci: the potentially nephritogenic types 2, 6 and 12, and 4 strains belonging to types M 39, M 46 and M 22 or M 62, the nephritogenic capacity of which is unknown. Two of 5 strains isolated from patients with acute post-streptococcal glomerulonephritis (AGN) and 19/28 type T 12, SOR[serum opacity reaction]-typed strains, isolated during an epidemic in a kindergarten with associated cases of AGN, bound aggregates. There may be an association between the capacity to bind aggregates in the presence of serum and the serological types of group A streptococci involved in acute nephritis following pharyngeal infection.