Consideration of some aspects of human malaria

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Abstract
The specificity of immune processes and the reproductive capacity of pre-erythrocytic schizonts indicate that the density of viable sporozoites inoculated may be a factor of importance in shaping the pattern of malaria in both the individual and the community. Strain specificity of immunity is discussed and attention drawn to the need for careful control of the size of challenging infections in the course of studies designed to elucidate intra-species differences in plasmodial antigenicity.

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