Amino acid activation with adenosine 5′-phosphorimidazolide
- 1 March 1978
- journal article
- research article
- Published by Springer Nature in Journal of Molecular Evolution
- Vol. 11 (1) , 9-16
- https://doi.org/10.1007/bf01768020
Abstract
Summary Amino acids are activated by reaction with adenosine 5′-phosphorimidazolide in aqueous imidazole buffers. If adenosine 5′-(O-methylphosphate), an analogue of the 3′-terminus of t-RNA is present, 2′(3′)-O-aminoacyladenosine 5′-(O-methylphosphate) is formed. Fifteen percent of this compound accumulated at pH 5.8, but less was formed at higher pHs. The highest efficiency of utilization of ImpA attained in our experiments was about 24%. Analogous reactions occured with several other amino acids, including a number that have functional side-chains.Keywords
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