Retinoic acid decreases retinoic acid and triiodothyronine nuclear receptor expression in the liver of hyperthyroidic rats
- 28 September 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 310 (2) , 101-105
- https://doi.org/10.1016/0014-5793(92)81306-7
Abstract
Retinoic acid (RA) and triiodothyronine (T3) exert many of their actions by binding to specific nuclear receptors (respectively, RA receptor (RAR) and T3) receptor (TR) belonging to a ‘superfamily’ of receptors. Some heterologous regulation of these receptors has been shown, and in particular regulation of the maximum binding capacity of TR by either retinol or RA. Now, using hyperthyroidic rats as a model, the effect of RA on binding capacity and on the mRNA levels of TR and RAR was investigated. The results show that the benefit of vitamin A treatment for the hyperthyroidic state, which has been described for a long time, could be the result of a down‐heteroregulation of TR by RA, the active metabolite of retinol.Keywords
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