The Gastrointestinal Tract and Iron Absorption
Open Access
- 1 October 1963
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 22 (4) , 416-428
- https://doi.org/10.1182/blood.v22.4.416.416
Abstract
1. Using Fe59 and whole body counting, various aspects of gastrointestinal absorption of iron salts were studied in normal, iron-loaded, and iron-deficient rats. 2. Following a single intragastric dose of iron, peak small intestinal uptake was observed by 30 to 60 minutes with subsequent gradual loss over 24-hour period. 3. Iron absorption showed two phases, an initial period of rapid absorption lasting up to 2 hours during which 60 to 80 per cent of total absorption into carcass took place. The remainder took place at a slow rate over the subsequent 12 to 20 hours. 4. Depending on the relationship between body iron stores and dose of administered iron, the intestine may take up more iron than is ultimately transferred to plasma. A variable amount of this iron is lost when the epithelial cell is sloughed into the gastrointestinal lumen. 5. Regulation of iron absorption appears to involve two steps, mucosal uptake and transfer to the blood.Keywords
This publication has 14 references indexed in Scilit:
- Measurement of Total Body Iron59 in Animals Using Whole-Body Liquid Scintillation DetectorsExperimental Biology and Medicine, 1962
- Kinetics of iron absorption in normal dogsAmerican Journal of Physiology-Legacy Content, 1961
- Active transport of Fe59 by everted segments of rat duodenumAmerican Journal of Physiology-Legacy Content, 1960
- IRON ABSORPTION .3. THE INFLUENCE OF IRON STORES ON IRON ABSORPTION IN THE NORMAL SUBJECT1960
- Studies on Erythropoiesis. XIV. The Relationship of Humoral Stimulation to Iron AbsorptionBlood, 1959
- A STUDY OF HISTOCHEMICAL IRON USING TRACER METHODS1949
- STUDIES IN IRON TRANSPORTATION AND METABOLISMBlood, 1948
- FERRITIN .9. INCREASE OF THE PROTEIN APOFERRITIN IN THE GASTROINTESTINAL MUCOSA AS A DIRECT RESPONSE TO IRON FEEDING - THE FUNCTION OF FERRITIN IN THE REGULATION OF IRON ABSORPTION1946
- RADIOACTIVE IRON ABSORPTION BY GASTRO-INTESTINAL TRACTThe Journal of Experimental Medicine, 1943
- RADIOACTIVE IRON AND ITS METABOLISM IN ANEMIAThe Journal of Experimental Medicine, 1939