PROTECTION OF MICE AGAINST MALARIA BY A KILLED VACCINE - DIFFERENCES IN EFFECTIVENESS AGAINST P-YOELII AND P-BERGHEI

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 33  (4) , 507-515
Abstract
(C57B1 .times. Balb/c)F1 mice are normally killed by a strain of the malaria parasite P. yoelii, but they can be fully protected by a killed vaccine. The best results were obtained with saponin-lysed parasitized cells subsequently fixed with 0.06% formalin and injected i.v. with the adjuvant Bordetella pertussis, though good protection was also obtained without the adjuvant. The protection was specific and at least partly mediated by a serum factor. A similar regime gives little or no protection against P. berghei. Possible reasons for this difference are considered, and the mechanisms by which vaccination works against P. yoelii are discussed.