Efavirenz Intoxication Due to Slow Hepatic Metabolism
Open Access
- 1 February 2005
- journal article
- case report
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 40 (3) , e22-e23
- https://doi.org/10.1086/427031
Abstract
We describe a human immunodeficiency virus–positive woman who presented with severe psychosis while she was receiving therapy with efavirenz. Her plasma efavirenz level was excessively high. Genetic investigation showed that she was homozygous for the CYP2B6 G516T allele, resulting in slow hepatic metabolism. After the dosage of efavirenz was lowered, all neuropsychiatric symptoms subsided.Keywords
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