Clonal Evolution of Marker Chromosomes in a Case of Myelofibrosis with Myeloid Metaplasia and Myeloblastic Transformation

Publisher Website
Google Scholar
Abstract
The diverse spectrum of acquired chromosome abnormalities in a female patient with myelofibrosis and myeloid metaplasia was described. A sequence of karyotypic evolution involving a ring chromosome was postulated. The terminal clinical picture was unusual in that there was obstructive renal failure from extramedullary myeloblastic transformation and infiltration of the bladder; this was also present in other sites. Initially neutrophils showed low alkaline phosphatase activity but later showed 2 distinct populations in which cells had high activity or none.