Mechanism of the Side Chain Degradation of Progesterone by Microorganisms.
- 1 January 1967
- journal article
- research article
- Published by Danish Chemical Society in Acta Chemica Scandinavica
- Vol. 21 (5) , 1297-1303
- https://doi.org/10.3891/acta.chem.scand.21-1297
Abstract
The degradation of the side chain of progesterone by Aspergillus flavus and Penicillium lilacinum has been studied. A. flavus cleaves the side chain via an enzymatic Bayer-Williger-oxidation of progesterone to testosterone acetate. This intermediate is then hydrolyzed to acetic acid and testosterone. The testosterone is then oxidized to [DELTA]4 -androstene-3,17-dlone. P. lilacinum more directly oxidizes progesterone to [DELTA]4-androstene-3,17-dione and no testosterone acetate is formed. P. lilacinum easily oxidizes 17a-hydroxyprogesterone to 4-androstene-3,17-dione, while A. flavus leaves this steroid unaffected.This publication has 5 references indexed in Scilit:
- Substrate specificity in steroid side-chain degradation by microorganismsBiochimica et Biophysica Acta (BBA) - General Subjects, 1964
- Purification and Properties of Steroid Esterase from Nocardia restrictusJournal of Biological Chemistry, 1963
- Mechanisms of steroid oxidation by microorganismsBiochimica et Biophysica Acta, 1962
- INTERMEDIATES IN THE METABOLISM OF STEROIDS BY PENICILLIUM LILACINUMJournal of Bacteriology, 1962
- ASSESSMENT OF THE FUNCTIONAL CAPACITY OF THE ADRENAL CORTEX. I. ESTABLISHMENT OF NORMAL VALUES*Journal of Clinical Endocrinology & Metabolism, 1958