EO9 phase II study in advanced breast, gastric, pancreatic and colorectal carcinoma by the EORTC Early Clinical Studies Group
- 1 October 1996
- journal article
- clinical trial
- Published by Elsevier in European Journal Of Cancer
- Vol. 32 (11) , 2019-2022
- https://doi.org/10.1016/0959-8049(96)00226-2
Abstract
No abstract availableKeywords
This publication has 11 references indexed in Scilit:
- DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?British Journal of Cancer, 1995
- Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidaseBritish Journal of Cancer, 1995
- Phase I and Pharmacologic Study of the Novel Indoloquinone Bioreductive Alkylating Cytotoxic Drug E09JNCI Journal of the National Cancer Institute, 1994
- CyclopropamitosenesAnti-Cancer Drugs, 1994
- Relative importance of DT-diaphorase and hypoxia in the bioactivation of e09 by human lung tumor cell linesInternational Journal of Radiation Oncology*Biology*Physics, 1994
- Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expressionBiochemical Pharmacology, 1994
- Unusually marked hypoxic sensitization to indoloquinone E09 and mitomycin C in a human colon‐tumour cell line that lacks DT‐diaphorase activityInternational Journal of Cancer, 1994
- EO9: A novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical modelsEuropean Journal Of Cancer, 1993
- In vitro activity of the novel indoloquinone EO-9 and the influence of pH on cytotoxicityBritish Journal of Cancer, 1992
- Mitomycin analogs I. Indoloquinones as (potential) bisalkylating agentsTetrahedron, 1987