Bicarbonate and the trans-endothelial short circuit current of human cornea

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Abstract
Experiments were performed in vitro, to determine the effect of HCO3- concentration on human cornea endothelial potential difference, short circuit current and resistance. Decreasing the HCO3- concentration resulted in a reversible and parallel fall in potential differences and short circuit current, whereas resistance remained unchanged. Apparently HCO3- is a necessary component of the mechanisms that generate trans-endothelial short circuit current. Similarities between data derived from rabbit, ox and human suggest that a common underlying HCO3- dependent mechanism is operating in these species.