β‐Endorphin: Synthesis and properties of analogs with replacement of lysine residues by arginine
- 1 October 1982
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 20 (4) , 308-311
- https://doi.org/10.1111/j.1399-3011.1982.tb00895.x
Abstract
Human β‐endorphin analogs, [Arg9,19,24,28,29]‐β‐endorphin (I) and [Arg24,28,29]‐β‐endorphin (II), have been synthesized by the solid‐phase method. Peptide II had 86% of the analgesic potency and 216% of the receptor binding activity of the parent molecule. Peptide I had only 18% analgesic potency but its binding activity was more than three time greater than that of human β‐endorphin.Keywords
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