Effects of Acutely Induced Ischemic Heart Failure on Myocardial High Energy Phosphate Stores

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Abstract
The effects of acutely induced ischemic heart failure on myocardial high energy phosphate stores were studied in dogs following an abrupt reduction (average 40%) of left main coronary arterial flow. Left ventricular biopsies were obtained before and during the onset of heart failure. Myocardial ATP stores were unchanged (control, 6.65 [mu]moles/g; ischemia, 6.66 [mu]moles/g) at a time when left ventricular end-diastolic pressure had risen from 3.9-11.3 mm Hg and left ventricular stroke work had fallen from 7.9-4.9 g-m. The average myocardial creatine phosphate (CP) stores fell from 13.2 [mu]moles/g to 7.9 [mu]moles/g. These results indicate that acute ischemic heart failure is not initiated by a detectable depression in total myocardial ATP stores.