The Relative Anti-muscular Dystrophy Activity of the d- and l-Epimers of α-Tocopherol and of Other Tocopherols in the Chick

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Abstract
The relative anti-muscular dystrophy activities (AMDA) of the d- and l-epimers of α-tocopheryl acetate and of β- and γ-tocopherols determined in chick bioassay were found to be 1.46, 0.36, 0.12 and 0.05 units/mg, respectively, as compared with a reference standard dl-α-tocopheryl acetate (unofficial ANRC) which was assigned an AMDA value of 1.0 unit/mg. Blood plasma tocopherol analyses showed that prevention of muscular dystrophy was correlated directly with total plasma tocopherol levels and that 900 to 1025 μg tocopherol/100 ml of blood were present when muscular dystrophy was prevented completely.