Epidermal architecture, growth, and metabolism in acromegaly.
- 28 February 1976
- Vol. 1 (6008) , 496-497
- https://doi.org/10.1136/bmj.1.6008.496
Abstract
Epidermal architecture, replication, and anabolic activity were studied in six patients with acromegaly. Patients with acromegaly had significant larger viable epidermal cells than controls. The rates of incorporation of tritiated thymidine, proline, and histidine into skin slices in vitro was also significantly increased in acromegalic patients. The mean autoradiographic labelling indices after intracutaneous injection of triated thymidine were 8.4% in the acromegalic patients and 5.1% in the control group. None of the changes observed could be closely correlated with levels of serum growth hormone.Keywords
This publication has 7 references indexed in Scilit:
- Treatment of acromegaly.1973
- Lichen simplex: morphodynamic correlates*British Journal of Dermatology, 1973
- Sebum Excretion in AcromegalyBMJ, 1972
- THE APPLICATION OF AN IN VITRO TECHNIQUE TO THE STUDY OF EPIDERMAL REPLICATION AND METABOLISMBritish Journal of Dermatology, 1971
- Discrepancies between precursor uptake and DNA synthesis in mammalian cellsJournal of Cellular Physiology, 1969
- A direct effect of growth hormone on the incorporation of precursors into proteins and nucleic acids of perfused rat liverBiochemical Journal, 1967
- Effect of Human Growth Hormone on Growth of Cells in Tissue Culture1Endocrinology, 1962