Pharmacological and therapeutic directions in ADHD: Specificity in the PFC
Open Access
- 1 January 2008
- journal article
- Published by Springer Nature in Behavioral and Brain Functions
- Vol. 4 (1) , 12
- https://doi.org/10.1186/1744-9081-4-12
Abstract
Recent directions in the treatment of ADHD have involved both a broadening of pharmacological perspectives to include nor-adrenergic as well as dopaminergic agents. A review of animal and human studies of pharmacological and therapeutic directions in ADHD suggests that the D1 receptor is a specific site for dopaminergic regulation of the PFC, but optimal levels of dopamine (DA) are required for beneficial effects on working memory. Animal and human studies indicate that the alpha-2A receptor is also important for prefrontal regulation, leaving open the question of the relative importance of these receptor sites. The therapeutic effects of ADHD medications in the prefrontal cortex have focused attention on the development of working memory capacity in ADHD.Keywords
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