AN ACETYL DERIVATIVE OF HEPARIN
- 1 September 1947
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Research
- Vol. 25b (5) , 472-476
- https://doi.org/10.1139/cjr47b-054
Abstract
An acetyl derivative of heparin corresponding to one mole of acetyl per four hexose units has been prepared by passing ketene through a suspension of heparin in acetone. The derivative possesses the same biological activity as the original heparin. It can be deacetylated in neutral solutions without loss of activity by raised temperatures, and like heparin, it is inactivated in acid solution.Keywords
This publication has 4 references indexed in Scilit:
- Chemical Studies on Crystalline Barium Acid Heparinate1Journal of the American Chemical Society, 1943
- Observations on the structure of the barium salt of heparinBiochemical Journal, 1940
- Acetylation of Carbohydrates by KeteneJournal of the American Chemical Society, 1939
- THE EFFECT OF INTRAVENOUS INJECTIONS OF HEPARIN IN THE DOGAmerican Journal of Physiology-Legacy Content, 1938