Synthetic L. casei Factor (Folic Acid) in Treating Certain Anemias in Man

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Abstract
Synthetic Lactobacillus casei factor was given intra-musc. to 4 of the patients in amts. of 15 mg. daily for 19-20 days. A reticulocyte response occurred in each case from the 2d to the 6th day, reaching a maximum between the 5th and 9th days of treatment and lasting for 8-15 days. The red cell count and Hb conc. increased within a wk. and continued until the 24th to 43d day when the maximum was attained. The bone marrow approached normal in 4-6 wks. One patient with nutritional macrocytic anemia was treated with folic acid concentrate and synthetic L. casei factor (5-15 mg. daily for 7-10 days orally or intramuscularly). The hemoglobin and red cells increased. The maximum reticulocyte response to folic acid concentrate was 12%, and to synthetic L. casei factor, 8.8%.